Breslow R A, Ballard-Barbash R, Munoz K, Graubard B I
Epidemiology and Health Services Research Branch, Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341, USA.
Cancer Epidemiol Biomarkers Prev. 2001 Jul;10(7):805-8.
Our purpose was to study the association between long-term recreational physical activity and breast cancer in the Epidemiological Follow-up Study (NHEFS) of the first National Health and Nutrition Examination Survey (NHANES I, 1971-1975). The analytic cohort included 6160 women who were free of breast cancer at the first NHEFS follow-up in 1982-1984 and had interview data on recreational physical activity (low, moderate, and high) in 1982-1984 and 10 years earlier, in 1971-1975. We created categories of long-term (1982-1984 + 1971-1975) recreational physical activity: (a) consistently low; (b) moderate/inconsistent; and (c) consistently high. Data were analyzed using Cox proportional hazard regression models. A total of 138 women developed breast cancer between 1982-1984 and 1992. In women > or =50 years of age in 1982-1984, consistently high (versus consistently low) recreational physical activity was associated with a 67% reduction in breast cancer risk (n = 96 cases; relative risk, 0.33; 95% confidence interval, 0.14-0.82; P for trend = 0.03); in women <50 years of age (n = 42 cases), there was no association. Associations were not modified by body mass index or by weight gain as an adult. High recreational physical activity over the long-term may reduce breast cancer risk in women > or =50 years of age; in this sample, it did so regardless of weight history.
我们的目的是在第一次全国健康与营养检查调查（NHANES I，1971 - 1975年）的流行病学随访研究（NHEFS）中，研究长期休闲体育活动与乳腺癌之间的关联。分析队列包括6160名女性，她们在1982 - 1984年的第一次NHEFS随访时没有患乳腺癌，并且有1982 - 1984年以及10年前（1971 - 1975年）的休闲体育活动（低、中、高）访谈数据。我们创建了长期（1982 - 1984年 + 1971 - 1975年）休闲体育活动类别：（a）持续低水平；（b）中等/不持续；（c）持续高水平。使用Cox比例风险回归模型分析数据。1982 - 1984年至1992年期间共有138名女性患乳腺癌。在1982 - 1984年年龄≥50岁的女性中，持续高水平（相对于持续低水平）的休闲体育活动与乳腺癌风险降低67%相关（n = 96例；相对风险，0.33；95%置信区间，0.14 - 0.82；趋势P值 = 0.03）；在年龄<50岁的女性中（n = 42例），没有关联。关联不受体重指数或成年后体重增加的影响。长期高水平的休闲体育活动可能会降低年龄≥50岁女性的乳腺癌风险；在这个样本中，无论体重史如何都是如此。
