Naciazek-Wieniawska A, Wilczyńska-Wojtulewicz I
Pol J Pharmacol Pharm. 1975 May-Jun;27(3):245-50.
Indomethacin can be found in several crystalline forms, of which only gamma is allowed in therapy. To determine the possible correlation between indomethacin crystalline form and its absorption as well as acute toxicity, a cycle of experiments was undertaken on mice and rats. Significant differences in toxic activity of alpha and gamma forms were stated in mice. In rats, however, no influence of the crystalline form on toxicity or absorption was observed.
吲哚美辛有几种晶型，其中只有γ晶型可用于治疗。为了确定吲哚美辛晶型与其吸收以及急性毒性之间可能存在的相关性，在小鼠和大鼠身上进行了一系列实验。结果表明，小鼠体内α晶型和γ晶型的毒性活性存在显著差异。然而，在大鼠中，未观察到晶型对毒性或吸收有影响。
