Barasoain I, Rojo J M, Sunkel C, Portoles A
Int J Clin Pharmacol Biopharm. 1978 May;16(5):235-9.
Administration of indomethacin and ten different indomethacin derivatives led to a variable depression in the mice immume response to sheep red blood cells (SRBC) as shown either by direct hemolytic-plaque assay or hemagglutination tests. Compounds with a lower toxicity than indomethacin and predominant immunosuppressive or anti-inflammatory activity were obtained. According to the variations in the primary immune response and to their variable anti-inflammatory actions, the structure-activity relationships are documentted and some possible explanations, relative to their immunodepressive effect, are discussed.
给予吲哚美辛和十种不同的吲哚美辛衍生物后，小鼠对绵羊红细胞（SRBC）的免疫反应出现不同程度的抑制，这在直接溶血空斑试验或血凝试验中均有体现。获得了毒性低于吲哚美辛且具有主要免疫抑制或抗炎活性的化合物。根据初次免疫反应的变化及其不同的抗炎作用，记录了构效关系，并讨论了一些关于其免疫抑制作用的可能解释。
