Piperazine derivatives of dimethylxanthines. III. 1-Piperazinoethyltheobromines.

1-Beta-Chloroethyltheobromine (CETb) heated with piperazine in the medium of 2-methoxyethanol yields N,N'-bis-(theobrominyl-1-ethyl)-piperazine dihydrochloride (IIb) or 1-piperazinoethyltheobromine (I). The use of N-methyl, N-beta-hydroxyethyl, N-ethoxycarbonyl and N-phenylpiperazine for exchange of chlorine in CETb lead to corresponding 1-N-alkyl or N-arylpiperazinoethyltheobromines (III--VIa) isolated in the form of salts. The preliminary investigations for diuretic and cardiovascular activity of the obtained compounds were performed.