Misztal S, Chojnacka-Wójcik E, Bartyzel P, Moskal A, Tatarczyńska E, Wiczyńska B, Lewandowska A
Pol J Pharmacol Pharm. 1984 Nov-Dec;36(6):697-703.
Ten new compounds, N-aryl substituted piperazinealkylindanes, have been synthesized. The most active one 1-(2-[4-(3-chlorophenyl)-1-piperazinyl]-ethyl)-indane (compound 9), displayed evident central serotoninolytic properties in the 5-hydroxytryptamine (5-HTP) head twitch test in mice, as well as in the tryptamine convulsions test and the quipazine-stimulated hind paw flexor reflex test in rats.
已合成了十种新化合物，即N-芳基取代的哌嗪烷基茚满。其中活性最高的1-(2-[4-(3-氯苯基)-1-哌嗪基]-乙基)-茚满（化合物9），在小鼠的5-羟色胺（5-HTP）头部抽搐试验、大鼠的色胺惊厥试验和喹哌嗪刺激的后爪屈肌反射试验中均表现出明显的中枢性5-羟色胺分解特性。
