Rowe D C, Stever C, Chase D, Sherman S, Abramowitz A, Waldman I D
Graduate Committee in Genetics and Division of Family Studies and Human Development, Campus Box 210033, University of Arizona, Tucson, AZ 85721, USA.
Mol Psychiatry. 2001 Jul;6(4):429-33. doi: 10.1038/sj.mp.4000874.
The 7-repeat allele of the dopamine receptor D4 gene (DRD4) and the 10 repeat allele of the dopamine transporter gene (DAT1) have shown association and linkage with symptoms of attention deficit hyperactivity disorder (ADHD) in childhood. The parents of ADHD children (clinic group, n = 80 fathers and 107 mothers) and control children (control group, n = 42 fathers and 51 mothers) were the focus of this study. These parents reported retrospectively on their level of ADHD Inattention and Conduct Disorder symptoms in adolescence. In analyses of the relation of symptom levels to the DRD4 and DAT1 genotypes, fathers possessing the 7 repeat DRD4 allele had greater levels of both inattention and conduct disorder symptoms. Mothers with the 10/10 genotype had higher levels of inattention symptoms. Thus, genetic associations found in children may be replicable in their parents.
多巴胺受体D4基因（DRD4）的7重复等位基因和多巴胺转运体基因（DAT1）的10重复等位基因已显示出与儿童注意力缺陷多动障碍（ADHD）症状的关联和连锁关系。本研究的重点是ADHD儿童的父母（临床组，80名父亲和107名母亲）和对照儿童的父母（对照组，42名父亲和51名母亲）。这些父母回顾性报告了他们在青少年时期ADHD注意力不集中和品行障碍症状的水平。在分析症状水平与DRD4和DAT1基因型的关系时，拥有7重复DRD4等位基因的父亲在注意力不集中和品行障碍症状方面的水平更高。具有10/10基因型的母亲注意力不集中症状水平更高。因此，在儿童中发现的基因关联可能在其父母中得到复制。
