Kreienbühl G, Strittmatter J, Ayim E
Pflugers Arch. 1976 Nov 5;366(2-3):167-72. doi: 10.1007/BF00585873.
Blood gases were measured in hibernating and hypothermic animals as a biological model of clinical hypothermia. Blood gas analyses from hamsters and dormice were carried out with the aid of permanent arterial catheters during normothermia and hibernation. In golden hamster pH increased from 7.30 to 7.46 during hibernation and PaCO2 decreased from 59.7 to 40.5 mm Hg. In dormice pH increased from 7.24 to 7.44 and PaCO2 decreases from 38.5 to 27.4 mm Hg. The actual bicarbonate concentration increased from 29 to 52 mMol in golden hamsters and from 16 to 34 mMol in dormice during hibernation. In experiments with induced hypothermia in golden hamsters under ketamine-anaesthesia there was no correlation between temperature and PaCO2. Despite the slight decrease in PaCO2 during hibernation we conclude that PaCO2 rather than total carbon dioxide content is held constant when temperature is changed. During clinical hypothermia it will probably be safe to keep PaCO2 constant.
作为临床低温的生物学模型，对处于冬眠和低温状态的动物进行了血气测量。在正常体温和冬眠期间，借助永久性动脉导管对仓鼠和睡鼠进行了血气分析。在金黄仓鼠中，冬眠期间pH值从7.30升至7.46，动脉血二氧化碳分压（PaCO2）从59.7降至40.5毫米汞柱。在睡鼠中，pH值从7.24升至7.44，PaCO2从38.5降至27.4毫米汞柱。冬眠期间，金黄仓鼠的实际碳酸氢盐浓度从29毫摩尔升至52毫摩尔，睡鼠从16毫摩尔升至34毫摩尔。在氯胺酮麻醉下对金黄仓鼠进行诱导低温实验时，温度与PaCO2之间无相关性。尽管冬眠期间PaCO2略有下降，但我们得出结论，当温度变化时，保持恒定的是PaCO2而非总二氧化碳含量。在临床低温期间，维持PaCO2恒定可能是安全的。
