Shapre L G, Olney J W, Ohlendorf C, Lyss A, Zimmerman M, Gale B
Pharmacol Biochem Behav. 1975 Mar-Apr;3(2):291-8. doi: 10.1016/0091-3057(75)90160-4.
L-cysteine in doses of 1.2-1.3 mg/g, was administered to 4-day-old rats which were tested throughout development and as adults on a variety of behavioral tasks. Lesions of the type previously described from L-cysteine treatment were confirmed in several cortical and limbic structures. No neurodegenerative changes were observed in NaCl (10 mmoles/kg) controls. Surviving L-cysteine treated animals displayed no obvious impairments in motor ability or growth rate, but did show behavioral deficits when tested as adults on 3 behavioral tasks: spontaneous alternation; Lashley III maze; and pattern discrimination. Activity in the open field was significantly higher in the L-cysteine group at 20 days of age. Amphetamine, administered in doses of 1.5 to 3.0 mg/kg, had no differential effects on open-field activity in the two groups. The behavioral changes observed in L-cysteine treated animals is similar to that which has been reported in adult rats with extensive hippocampal damage.
给4日龄大鼠注射剂量为1.2 - 1.3毫克/克的L-半胱氨酸，并在其整个发育过程以及成年后对其进行各种行为任务测试。在几个皮质和边缘结构中证实了先前描述的L-半胱氨酸治疗所致的损伤类型。在氯化钠（10毫摩尔/千克）对照组中未观察到神经退行性变化。存活的经L-半胱氨酸治疗的动物在运动能力或生长速率方面未表现出明显损伤，但在成年后进行3项行为任务测试时确实表现出行为缺陷：自发交替；拉什利III型迷宫；以及模式辨别。在20日龄时，L-半胱氨酸组在旷场中的活动明显更高。以1.5至3.0毫克/千克的剂量给予苯丙胺，对两组在旷场中的活动没有差异影响。在经L-半胱氨酸治疗的动物中观察到的行为变化与在患有广泛海马损伤的成年大鼠中所报道的相似。
