Mohsen A, Omar M E, Farghaly A M, El Dine S A
Pharmazie. 1975 Feb;30(2):83-4.
The use of different alkyl halides as effective cyclodesulfurizing agents was thoroughly studied. N-phenyl-,N'-[o-aminophenyl]-thiourea when treated with different alkyl halides gave rise to 2-phenyl-aminobenzimidazole. The optimum conditions for such cyclodesulfurization reaction were established by using eight equivalents of the alkyl halide, ethyl alcohol as solvent, and 8 h reflux. The reaction was also successfully applied to N-o-tolyl (benzyl or n-butyl)-N'-[o-aminophenyli1-thioureas to give rise to the corresponding 2-substituted aminobenzimidazoles.
对使用不同的卤代烷作为有效的环化脱硫剂进行了深入研究。N-苯基-N'-[邻氨基苯基]硫脲与不同的卤代烷反应生成2-苯基氨基苯并咪唑。通过使用八当量的卤代烷、乙醇作为溶剂并回流8小时，确定了这种环化脱硫反应的最佳条件。该反应还成功应用于N-邻甲苯基（苄基或正丁基）-N'-[邻氨基苯基]硫脲，以生成相应的2-取代氨基苯并咪唑。
