Monzón M E, Varas M M, De Barioglio S R
Laboratorio de Fisiología, Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba (UNC), 5000 Córdoba, Argentina.
Peptides. 2001 Jul;22(7):1043-7. doi: 10.1016/s0196-9781(01)00439-9.
In this study, the involvement of nitric oxide (NO) in the mechanism of anxiety was investigated. The rats received an intraamygdaline or intrahippocampal injection of the nitric oxide synthase inhibitor, N(G)-nitro-l-arginine (L-NOARG), and were then tested in the plus-maze test. L-NOARG induced a decrease in the time spent by rats in the open arms. Conversely, the administration of the melanin-concentrating hormone (MCH) into these structures increased the number of entries into the open arms as well as the time spent on them. MCH injected in rats pretreated with L-NOARG also was able to revert the anxiogenic effects of L-NOARG in amygdala.
在本研究中，对一氧化氮（NO）在焦虑机制中的作用进行了研究。给大鼠杏仁核内或海马内注射一氧化氮合酶抑制剂N（G）-硝基-L-精氨酸（L-NOARG），然后在十字迷宫试验中进行测试。L-NOARG使大鼠在开放臂停留的时间减少。相反，向这些结构中注射黑色素聚集激素（MCH），增加了进入开放臂的次数以及在开放臂上停留的时间。给预先用L-NOARG处理的大鼠注射MCH，也能够逆转L-NOARG在杏仁核中的致焦虑作用。
