Monzon M E, de Souza M M, Izquierdo L A, Izquierdo I, Barros D M, de Barioglio S R
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Peptides. 1999 Dec;20(12):1517-9. doi: 10.1016/s0196-9781(99)00164-3.
The purpose of the present study was to evaluate the possible effect of melanin-concentrating hormone (MCH) on learning and memory by using the one-trial step-down inhibitory avoidance test in rats. The peptide was infused into hippocampus, amygdala, and entorhinal cortex. MCH caused retrograde facilitation when given at 0 or 4 h post-training into hippocampus, but only at 0 h into amygdala. From these results, it seems that MCH modulates memory early after training by acting on both the amygdala and hippocampus and, 4 h after training, on the hippocampus.
本研究的目的是通过在大鼠中使用一次性被动回避抑制试验来评估黑色素浓集激素（MCH）对学习和记忆的可能影响。将该肽注入海马体、杏仁核和内嗅皮质。当在训练后0小时或4小时注入海马体时，MCH会引起逆行性促进作用，但仅在训练后0小时注入杏仁核时才会出现这种情况。从这些结果来看，MCH似乎在训练后早期通过作用于杏仁核和海马体来调节记忆，而在训练后4小时则仅作用于海马体。
