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大鼠快肌和慢肌中糖原酶的发育变化

Developmental changes of glycogen enzymes in fast and slow muscles of the rat.

作者信息

Villa-Moruzzi E, Locci-Cubeddu T, Bergamini E

出版信息

Growth. 1979 Jun;43(2):73-9.

PMID:114455
Abstract

Glycogen synthase (GS), Branching enzyme (BE), Glycogen Phosphorylase (GPho) and the Debranching enzyme (DE) activities were studied in the white extensor digitorum longus (ELD) and in the red soleus (S) muscles of rats during the developmental period from birth to the young adulthood. During the first days of postnatal life all enzyme activities similarly increase in both ELD and in S. BE and DE seem to rise faster and reach the adult levels earlier than GS and GPho. Significant differences can be seen between ELD and S by age 14--21 days: glycogenolytic enzymes rise higher in the ELD, GS activity is similar in both muscles whereas BE activity is higher in S. All these develop changes are completed in 25 days. Thereafter, only GPho activity in the ELD continues to slowly increase.

摘要

在从出生到年轻成年的发育阶段,对大鼠的白色趾长伸肌(ELD)和红色比目鱼肌(S)中的糖原合酶(GS)、分支酶(BE)、糖原磷酸化酶(GPho)和脱支酶(DE)活性进行了研究。在出生后的头几天,ELD和S中的所有酶活性均以相似的方式增加。BE和DE似乎上升得更快,并且比GS和GPho更早达到成年水平。在14 - 21日龄时,ELD和S之间可以看到显著差异:ELD中的糖原分解酶升高得更高,两种肌肉中的GS活性相似,而S中的BE活性更高。所有这些发育变化在25天内完成。此后,仅ELD中的GPho活性继续缓慢增加。

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