An unexpected selectivity of a propranolol-derived molecular imprint for tamoxifen.

作者信息

Martin P D, Wilson T D, Wilson I D, Jones G R

机构信息

Department of Drug Metabolism and Pharmacokinetics, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, UK SK10 4TG.

出版信息

Analyst. 2001 Jun;126(6):757-9. doi: 10.1039/b102424h.

DOI:10.1039/b102424h

PMID:11445932

Abstract

During the evaluation of molecular imprinted polymers (MIPs) prepared against the drug tamoxifen a propranolol-derived MIP was used as a positive control. Surprisingly the propranolol-derived MIP showed considerable selectivity towards tamoxifen, and was indeed much more selective than the MIP prepared using tamoxifen as the imprint molecule. The consequences of this unexpected, cross reactivity for the use of MIPs in analytical chemistry is discussed.

摘要