Kantarovich Keren, Tsarfati Inbal, Gheber Levi A, Haupt Karsten, Bar Ilana
Department of Physics, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Anal Chem. 2009 Jul 15;81(14):5686-90. doi: 10.1021/ac900418x.
Molecularly imprinted polymer (MIP) droplets were printed using a pipet or a nano fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces, to directly monitor the uptake and release of a template molecule, the beta-blocking drug propranolol, by SERS. The monitored SERS bands can be related to the template, allowing for its detection but also identification in the MIP. This is an advantage if the technique is to be used during the development phase of MIPs as microstructures, but equally for the readout of MIP-based biochips.
使用移液器或纳米 fountain 笔将分子印迹聚合物（MIP）微滴打印在表面增强拉曼散射（SERS）活性表面上，以通过 SERS 直接监测模板分子（β 受体阻滞剂普萘洛尔）的摄取和释放。监测到的 SERS 谱带可与模板相关联，从而不仅能够检测模板，还能在 MIP 中对其进行识别。如果该技术要在 MIP 作为微结构的开发阶段使用，这是一个优势，同样对于基于 MIP 的生物芯片的读出也是如此。
