Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellert ter 4., H-1111 Budapest, Hungary.
MTA-BME Research Group of Technical Analytical Chemistry, Szent Gellert ter 4., H-1111 Budapest, Hungary.
Molecules. 2018 May 29;23(6):1298. doi: 10.3390/molecules23061298.
One of the main reasons for making molecularly imprinted polymers (MIPs) has been that MIPs interact selectively with a specific target compound. This claim is investigated here with the example of a widely used type of noncovalent MIP, the MIP for the beta blocker propranolol. Adsorption isotherms of this MIP and of a nonimprinted control polymer (NIP), respectively, have been measured with a series of compounds in the porogen solvent acetonitrile. The results, visualized as "selectivity ladders", show that the MIP binds propranolol and many other amines better than the NIP does, but the selectivity of the MIP is actually inferior to that of the NIP. The selectivity of either polymer for propranolol is modest against many amines, but is remarkable with respect to other compounds. The contribution of imprinting towards selectivity can be better appreciated when three MIPs, made with different amine templates, are compared among themselves. Each MIP is seen to bind its own template slightly better than the other two MIPs do. In media different from the porogen, the selectivity patterns may change substantially. Propranolol seems to have properties that make it stand high on the selectivity scale in different solvents, albeit for different reasons.
制备分子印迹聚合物（MIP）的主要原因之一是 MIP 可以与特定目标化合物选择性地相互作用。这里以广泛使用的非共价 MIP 之一，即β受体阻滞剂普萘洛尔的 MIP 为例进行了研究。分别用一系列溶剂乙腈中的化合物测量了该 MIP 和非印迹对照聚合物（NIP）的吸附等温线。结果以“选择性阶梯”的形式可视化，表明 MIP 比 NIP 更能结合普萘洛尔和许多其他胺，但 MIP 的选择性实际上不如 NIP。两种聚合物对许多胺的选择性都适中，但相对于其他化合物来说则很显著。当将三种用不同胺模板制备的 MIP 相互比较时，可以更好地理解印迹对选择性的贡献。每种 MIP 对其自身模板的结合都比另外两种 MIP 稍好。在与致孔剂不同的介质中，选择性模式可能会发生很大变化。尽管原因不同，但普萘洛尔似乎具有使其在不同溶剂中处于高选择性尺度的特性。
