Saviola G, Avanzi S, Grioni G
Fondazione Salvatore Maugeri Clinica del Lavoro e della Riabilitazione IRCCS, Servizi Aggregati di Reumatologia e di Neuropsicologia, Castel Goffredo, Italia.
Clin Ter. 2001 Mar-Apr;152(2):131-4.
The rheumatism induced by anticonvulsants has been described in literature mostly because of phenobarbital therapy. The possible onset of this clinical picture due to other antiepileptic drugs is unusual and not well defined. We report the case of a 87-year-old female, affected by partial seizures treated with carbamazepine for 20 years, who came to our observation for the onset of disturbances that clearly resemble the classic syndrome of rheumatism induced by barbiturates: the diagnostic hypothesis of a drug side effect was confirmed by the marked clinical improvement of the patient after carbamazepine was stopped and substituted by gabapentin.
抗惊厥药所致的风湿病在文献中多有描述，主要是由于苯巴比妥治疗。由其他抗癫痫药物导致这种临床表现的情况不常见且定义不明确。我们报告一例87岁女性病例，她因部分性癫痫发作接受卡马西平治疗20年，因出现明显类似于巴比妥类药物所致经典风湿病综合征的症状前来就诊。停用卡马西平并换用加巴喷丁后患者临床症状明显改善，证实了药物副作用的诊断假说。
