Pekin T, Kavak Z, Yildizhan B, Kaya H
Department of Gynecologic Oncology, Marmara University Hospital, Istanbul, Turkey.
Eur J Gynaecol Oncol. 2001;22(2):160-3.
To evaluate a cohort of women with primary invasive carcinomas of the uterine cervix, and to compare the biological characteristics and behavior of a cohort of adenosquamous carcinomas with a cohort of adenocarcinomas and squamous cell carcinomas.
One hundred and fourteen cases of primary invasive cervical carcinoma presenting between 1 January 1987 and 31 December 1997 were studied. Sixteen (14%) women with adenosquamous cell carcinomas and eight (7%) adenocarcinomas were compared with 90 (79%) women with squamous cell carcinomas. Patients with Stage Ib and IIa were treated by radical hysterectomy and pelvic lymph node dissection. All patients with stage IIb and over were treated by radiation. Patients with bulky, large, barrel-shaped lesions were selected for treatment by a combination of radiation and extrapelvic hysterectomy.
The corrected survival rate for stage Ib patients with adenosquamous cell carcinoma was only 27.2%, compared with a 92.2% corrected survival rate for squamous cell, and a 100% corrected survival rate for adenocarcinoma.
There is a higher proportion of adenosquamous cell and adenocarcinoma of the cervix than generally appreciated. The epidemiological risk factors associated with adenosquamous carcinomas of the cervix are more similar to those of squamous cell carcinomas than of adenocarcinomas. The survival difference between two groups is explained by effects of clinical stage, nodal spread, and vascular space involvement.
评估一组原发性子宫颈浸润癌女性患者，并比较腺鳞癌患者与腺癌和鳞状细胞癌患者的生物学特征及行为。
研究了1987年1月1日至1997年12月31日期间出现的114例原发性宫颈浸润癌病例。将16例（14%）腺鳞癌女性患者和8例（7%）腺癌患者与90例（79%）鳞状细胞癌女性患者进行比较。Ib期和IIa期患者接受根治性子宫切除术和盆腔淋巴结清扫术。所有IIb期及以上患者接受放射治疗。选择有巨大、大的桶状病变的患者接受放疗和盆腔外子宫切除术联合治疗。
Ib期腺鳞癌患者的校正生存率仅为27.2%，而鳞状细胞癌的校正生存率为92.2%，腺癌的校正生存率为100%。
宫颈腺鳞癌和腺癌的比例高于普遍认识。与宫颈腺鳞癌相关的流行病学危险因素与鳞状细胞癌的更相似，而非腺癌。两组之间的生存差异由临床分期、淋巴结转移和脉管间隙受累的影响来解释。
