Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Int J Gynaecol Obstet. 2011 Nov;115(2):183-7. doi: 10.1016/j.ijgo.2011.06.011. Epub 2011 Aug 31.
To examine the effect of carcinoma cell type on tumor characteristics, tumor spread, tumor recurrence, and survival of patients with early-stage cervical cancer who had radical hysterectomy and pelvic lymphadenectomy.
Data from 499 patients with stage IA to IIA cervical carcinoma who received primary surgical treatment from 2003 to 2005 at Chiang Mai University were retrospectively reviewed with regard to 3 histologic types; squamous cell carcinoma (SCC), adenocarcinoma (AC), and adenosquamous carcinoma (AS).
Among the 499 patients, 71.1% had SCC, 23.4% had AC, and 5.4% had AS. There was no significant difference in stage, tumor size, tumor characteristics, or rate of loco-regional spread. A higher proportion of women with SCC needed adjuvant radiation (P=0.001). Five-year recurrence-free survival (RFS) and overall survival (OS) were comparable among the groups. Among patients with pelvic node metastasis, 5-year RFS and OS were significantly lower in those with AC than in those with SCC (RFS, 66.1% versus 86.4%, P=0.02; OS, 68.2% versus 88.2%, P=0.05).
There was no difference among SCC, AC, and AS in most tumor characteristics, spread, recurrence, and survival in patients with early-stage cervical cancer. Among patients with pelvic lymph node metastasis, AC was associated with less favorable outcomes than SCC.
研究在接受根治性子宫切除术和盆腔淋巴结切除术的早期宫颈癌患者中，癌细胞类型对肿瘤特征、肿瘤播散、肿瘤复发和生存的影响。
回顾性分析了 2003 年至 2005 年在清迈大学接受初次手术治疗的 499 例 IA 期至 IIA 期宫颈癌患者的 3 种组织学类型（鳞状细胞癌[SCC]、腺癌[AC]和腺鳞癌[AS]）的数据。
在 499 例患者中，71.1%为 SCC，23.4%为 AC，5.4%为 AS。各组织学类型间的分期、肿瘤大小、肿瘤特征和局部区域扩散率无显著差异。SCC 患者更需要辅助放疗（P=0.001）。各组的 5 年无复发生存率（RFS）和总生存率（OS）相当。在有盆腔淋巴结转移的患者中，AC 患者的 5 年 RFS 和 OS 明显低于 SCC 患者（RFS：66.1%比 86.4%，P=0.02；OS：68.2%比 88.2%，P=0.05）。
在早期宫颈癌患者中，SCC、AC 和 AS 之间在大多数肿瘤特征、播散、复发和生存方面无差异。在有盆腔淋巴结转移的患者中，AC 的结局不如 SCC 理想。
