人型支原体中选择性表面脂蛋白的耦合相变量表达和表位掩盖增加了表面表型多样性。
Coupled phase-variable expression and epitope masking of selective surface lipoproteins increase surface phenotypic diversity in Mycoplasma hominis.
作者信息
Zhang Q, Wise K S
机构信息
Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA.
出版信息
Infect Immun. 2001 Aug;69(8):5177-81. doi: 10.1128/IAI.69.8.5177-5181.2001.
Abstract
A new mechanism expanding mycoplasmal surface diversity is described. Exposure of surface epitopes on a constitutively expressed membrane protein (P56) of Mycoplasma hominis was subject to high-frequency phase variation due to phase-variable expression of the P120 antigen and its selective masking of P56 epitopes. Phase-variable masking may confer previously unrealized adaptive capabilities on mycoplasmas.
摘要
描述了一种扩展支原体表面多样性的新机制。人型支原体组成性表达的膜蛋白（P56）上的表面表位暴露，由于P120抗原的相变异表达及其对P56表位的选择性掩盖，而经历高频相变异。相变异掩盖可能赋予支原体以前未实现的适应能力。
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