You Xiao-xing, Zeng Yan-hua, Wu Yi-mou
Institute of Pathogenic Biology, School of Medicine, Nanhua University, Hengyang 421001, China.
J Zhejiang Univ Sci B. 2006 May;7(5):342-50. doi: 10.1631/jzus.2006.B0342.
Mycoplamas are a group of wall-less prokaryotes widely distributed in nature, some of which are pathogenic for humans and animals. There are many lipoproteins anchored on the outer face of the plasma membrane, called lipid-associated membrane proteins (LAMPs). LAMPs are highly antigenic and could undergo phase and size variation, and are recognized by the innate immune system through Toll-like receptors (TLR) 2 and 6. LAMPs can modulate the immune system, and could induce immune cells apoptosis or death. In addition, they may associate with malignant transformation of host cells and are also considered to be cofactors in the progression of AIDS.
支原体是一类无细胞壁的原核生物,广泛分布于自然界,其中一些对人和动物具有致病性。在质膜外表面锚定着许多脂蛋白,称为脂质相关膜蛋白(LAMPs)。LAMPs具有高度抗原性,可发生相位和大小变异,并通过Toll样受体(TLR)2和6被固有免疫系统识别。LAMPs可调节免疫系统,并可诱导免疫细胞凋亡或死亡。此外,它们可能与宿主细胞的恶性转化有关,也被认为是艾滋病进展的辅助因子。