Marcucci R, Brunelli T, Giusti B, Fedi S, Pepe G, Poli D, Prisco D, Abbate R, Gensini G F
Dipartimento Area Critica Medico-Chirurgica, Sez. Clinica Medica Gen e Cardiologia, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy.
Am J Clin Pathol. 2001 Jul;116(1):56-60. doi: 10.1309/7A33-8EQ4-QT98-3TPX.
Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis, whereas few data are available on the total cysteine (tCy) levels in thrombophilic patients. We studied 82 patients with a previous myocardial infarction (MI; group 1), 68 patients with a previous deep venous thrombosis (group 2), and 100 control subjects (group 3). We assayed total homocysteine (tHcy) and tCy levels by high-performance liquid chromatography with fluorimetric detection. The odds ratios (ORs) for high levels of tCy and tHcy in venous thrombosis and MI were markedly increased in group 1 (fasting tCy: OR, 3.6; 95% confidence interval [CI], 1.6-11.2; postmethionine tCy: OR, 0.97; CI, 0.3-4.0; fasting tHcy: OR, 8.3; CI, 3.9-18.6; postmethionine tHcy: OR, 12.5; CI, 6.8-27.2) and in group 2 (fasting tCy: OR, 2.9; CI, 1.1-7.8; postmethionine tCy: OR, 0.86; CI 0.2-2.6; fasting tHcy: OR, 8.0; CI 3.6-18.0; postmethionine tHcy: OR, 11.0; CI, 6.0-22.1). Our data suggest that plasma tCy levels are a risk factor for venous thrombosis and MI independently of tHcy levels and that it may be appropriate to study both variables simultaneously to thoroughly study the methionine metabolism.
高同型半胱氨酸血症是动脉和静脉血栓形成的一个危险因素，而关于易栓症患者的总半胱氨酸（tCy）水平的数据却很少。我们研究了82例曾患心肌梗死（MI；第1组）的患者、68例曾患深静脉血栓形成的患者（第2组）以及100名对照者（第3组）。我们采用高效液相色谱荧光检测法测定总同型半胱氨酸（tHcy）和tCy水平。第1组（空腹tCy：比值比[OR]，3.6；95%置信区间[CI]，1.6 - 11.2；蛋氨酸负荷后tCy：OR，0.97；CI，0.3 - 4.0；空腹tHcy：OR，8.3；CI，3.9 - 18.6；蛋氨酸负荷后tHcy：OR，12.5；CI，6.8 - 27.2）和第2组（空腹tCy：OR，2.9；CI，1.1 - 7.8；蛋氨酸负荷后tCy：OR，0.86；CI 0.2 - 2.6；空腹tHcy：OR，8.0；CI 3.6 - 18.0；蛋氨酸负荷后tHcy：OR，11.0；CI，6.0 - 22.1）中，静脉血栓形成和MI患者中tCy和tHcy水平升高的比值比显著增加。我们的数据表明，血浆tCy水平是静脉血栓形成和MI的一个危险因素，独立于tHcy水平，并且同时研究这两个变量可能适合用于全面研究蛋氨酸代谢。
