Grecomoro G, La Sala F, Francavilla G
Orthopedics and Traumatology Unit, Department of Surgery and Anatomy, University of Palermo, Palermo, Italy.
Int J Tissue React. 2001;23(2):67-71.
The aim of the present study was to evaluate possible changes in synovial fluid viscosity in gonarthritic patients treated with intraarticular infiltration of hyaluronic acid. Thirty patients with radiologically proven (Stage III Kellgren) serious gonarthrosis, local pain and functional limitation were enrolled. All patients had reported at least 4-5 episodes of hydrarthrosis during the previous 12 months. Therefore, two different phases of their illness could be observed: a relatively silent phase of hydrarthrosis and a symptomatic phase. According to the protocol, one sample of synovial fluid was collected for evaluation of baseline viscosity (pretreatment); immediately afterwards, intraarticular administration of high molecular weight sodium hyaluronate (one 20 mg vial/week for 3 weeks) was initiated. During the entire treatment period and for 3 weeks following the end of treatment, intraarticular synovial fluid samples (one sample per week for 3 treatment weeks followed by a further 3 weeks as control) were collected to perform rheologic assessment and viscosimetric analysis. The results of this preliminary study show that exogenous administration of high molecular weight sodium hyaluronate induced normalization of hyaluronic acid viscosity values in patients with high and low baseline hyaluronic acid viscosity values.
本研究的目的是评估接受透明质酸关节腔内注射治疗的膝骨关节炎患者滑液粘度的可能变化。招募了30例经放射学证实（Kellgren III期）患有严重膝关节炎、局部疼痛和功能受限的患者。所有患者在过去12个月内均报告至少有4 - 5次关节积液发作。因此，可以观察到他们疾病的两个不同阶段：相对无症状的关节积液期和症状期。根据方案，采集一份滑液样本用于评估基线粘度（治疗前）；随后立即开始关节腔内注射高分子量透明质酸钠（每周1瓶20mg，共3周）。在整个治疗期间以及治疗结束后的3周内，采集关节腔内滑液样本（治疗的3周每周采集1份样本，随后再作为对照采集3周）以进行流变学评估和粘度分析。这项初步研究的结果表明，外源性给予高分子量透明质酸钠可使基线透明质酸粘度值高和低的患者的透明质酸粘度值恢复正常。
