Ohtani T, Takahashi A, Honda F, Ishiuchi S, Kurihara H, Inoue T, Nakazato Y, Sasaki T
Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Japan.
Ann Nucl Med. 2001 Apr;15(2):161-5. doi: 10.1007/BF02988610.
Central neurocytoma is a benign neuronal tumor with a favorable prognosis. This tumor is typically characterized by decreased uptake of 18F-fluorodeoxy glucose (FDG) and any increased uptake of FDG in patients suffering from this tumor would be highly unusual. A case of central neurocytoma with an intense FDG uptake, combined with atypical histopathological features and a high proliferation index is reported in this paper. A 45-year-old male had a two months' history of right hemiweakness. Magnetic resonance (MR) imaging showed a large tumor in the right lateral ventricle. Positron emission tomography (PET) with FDG revealed high glucose metabolism in the tumor. The histological diagnosis was central neurocytoma with atypical features characterized by microvascular proliferation. The MIB-1 labeling index, ordinarily smaller than 2.0%, was 7.0%. Conventional radiotherapy, with a total dose of 50 Gy, was administered after the surgical treatment. The patient returned to his normal daily activities after the cessation of radiation therapy.
中枢神经细胞瘤是一种预后良好的良性神经元肿瘤。该肿瘤的典型特征是18F-氟脱氧葡萄糖（FDG）摄取减少，而患有这种肿瘤的患者中FDG摄取增加则非常罕见。本文报道了一例FDG摄取强烈的中枢神经细胞瘤，伴有非典型组织病理学特征和高增殖指数。一名45岁男性有两个月的右侧半身无力病史。磁共振（MR）成像显示右侧侧脑室内有一个大肿瘤。FDG正电子发射断层扫描（PET）显示肿瘤内葡萄糖代谢增高。组织学诊断为具有微血管增生特征的非典型中枢神经细胞瘤。MIB-1标记指数通常小于2.0%，该病例为7.0%。手术治疗后给予总量为50 Gy的常规放疗。放疗结束后患者恢复了正常的日常活动。
