Hasegawa M, Adachi K, Nakamura S, Sato M, Waddington J L, Koshikawa N
Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda, Tokyo 101-8310, Japan.
Eur J Pharmacol. 2001 Jul 6;423(2-3):171-8. doi: 10.1016/s0014-2999(01)01110-4.
This study compared the effects of intracerebral injections of the dopamine D(1)-like receptor agents 3-methyl-6-chloro-7,8-dihydroxy-1-[3-methylphenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine (SK&F 83959) and [R]-3-methyl-7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SCH 23390) into the ventrolateral striatum or the shell of the nucleus accumbens on the synergistic induction of jaw movements by intravenous (i.v.) co-administration of [R]-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SK&F 38393) or SK&F 83959 with the dopamine D(2)-like receptor agonist, quinpirole. In the ventrolateral striatum, SCH 23390 and SK&F 83959 each blocked jaw movements induced by i.v. SK&F 38393 with quinpirole, while only SCH 23390 blocked i.v. SK&F 83959 with quinpirole. SCH 23390 was less effective in the accumbens shell than in the ventrolateral striatum, and SK&F 83959 was ineffective to block i.v. SK&F 38393 with quinpirole, while neither SCH 23390 nor SK&F 83959 blocked i.v. SK&F 83959 with quinpirole. As SK&F 83959 inhibits the stimulation of adenylyl cyclase via dopamine D(1A) receptors but acts as an agonist at a putative dopamine D(1)-like receptor site not linked to cyclase, an important role is indicated for non-cyclase-coupled dopamine D(1)-like receptor sites as well as dopamine D(1A) receptors in the regulation of jaw movements via dopamine D(1)-like/D(2)-like receptor synergism, particularly in the ventrolateral striatum.
本研究比较了向腹外侧纹状体或伏隔核壳内注射多巴胺D(1)样受体激动剂3-甲基-6-氯-7,8-二羟基-1-[3-甲基苯基]-2,3,4,5-四氢-1H-3-苯并氮杂卓（SK&F 83959）和[R]-3-甲基-7-氯-8-羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓（SCH 23390），对静脉注射[R]-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓（SK&F 38393）或SK&F 83959与多巴胺D(2)样受体激动剂喹吡罗联合给药协同诱导颌部运动的影响。在腹外侧纹状体中，SCH 23390和SK&F 83959均可阻断静脉注射SK&F 38393与喹吡罗诱导的颌部运动，而只有SCH 23390可阻断静脉注射SK&F 83959与喹吡罗诱导的颌部运动。SCH 23390在伏隔核壳中的作用效果不如在腹外侧纹状体中，SK&F 83959无法阻断静脉注射SK&F 38393与喹吡罗诱导的颌部运动，而SCH 23390和SK&F 83959均无法阻断静脉注射SK&F 83959与喹吡罗诱导的颌部运动。由于SK&F 83959可通过多巴胺D(1A)受体抑制腺苷酸环化酶的刺激，但在一个与环化酶无关的假定多巴胺D(1)样受体位点上起激动剂作用，这表明非环化酶偶联的多巴胺D(1)样受体位点以及多巴胺D(1A)受体在通过多巴胺D(1)样/D(2)样受体协同作用调节颌部运动中起重要作用，尤其是在腹外侧纹状体中。
