Adachi Kazunori, Hasegawa Megumi, Fujita Satoshi, Lee Jun, Cools Alexander R, Waddington John L, Koshikawa Noriaki
Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda, Tokyo 101-8310, Japan.
Eur J Pharmacol. 2003 Jul 18;473(1):47-54. doi: 10.1016/s0014-2999(03)01938-1.
The effect on jaw movements of intracerebral injections of the dopamine D1-like receptor agents SK&F 83959 (3-methyl-6-chloro-7,8-dihydroxy-1-[3-methylphenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine), SK&F 38393 ([R]-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) and SCH 23390 ([R]-3-methyl-7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) and of injections of the dopamine D2-like receptor agonist quinpirole into the ventrolateral striatum, accumbens shell or prefrontal cortex were studied. SK&F 38393 and SK&F 83959 injected into the ventrolateral striatum synergised with i.v. quinpirole; in the shell of accumbens, SK&F 38393 evidenced weaker synergism with quinpirole, while SK&F 83959 did not synergise with it; neither agent synergised with quinpirole in the prefrontal cortex. Co-injection of SCH 23390 or SK&F 83959 into the prefrontal cortex antagonised jaw movements induced by injection of SK&F 83959 into the ventrolateral striatum in combination with i.v. quinpirole. Injection of SK&F 83959 + quinpirole into the ventrolateral striatum, but not into the accumbens shell, resulted in synergism. These findings indicate a primary, but not exclusive, role for ventral striatal, non-cyclase-coupled dopamine D1-like receptors in the induction of jaw movements. These processes appear to require tonic activity of prefrontal cyclase-linked dopamine D1A [and/or D1B] receptors.
研究了向脑内注射多巴胺 D1 样受体激动剂 SK&F 83959（3 - 甲基 - 6 - 氯 - 7,8 - 二羟基 - 1 - [3 - 甲基苯基] - 2,3,4,5 - 四氢 - 1H - 3 - 苯并氮杂卓）、SK&F 38393（[R] - 7,8 - 二羟基 - 1 - 苯基 - 2,3,4,5 - 四氢 - 1H - 3 - 苯并氮杂卓）和 SCH 23390（[R] - 3 - 甲基 - 7 - 氯 - 8 - 羟基 - 1 - 苯基 - 2,3,4,5 - 四氢 - 1H - 3 - 苯并氮杂卓）以及向腹外侧纹状体、伏隔核壳或前额叶皮质注射多巴胺 D2 样受体激动剂喹吡罗对下颌运动的影响。向腹外侧纹状体注射 SK&F 38393 和 SK&F 83959 与静脉注射喹吡罗有协同作用；在伏隔核壳中，SK&F 38393 与喹吡罗的协同作用较弱，而 SK&F 83959 与它无协同作用；在这两种药物在前额叶皮质中均不与喹吡罗产生协同作用。将 SCH 23390 或 SK&F 83959 与向腹外侧纹状体注射 SK&F 83959 并静脉注射喹吡罗联合注射到前额叶皮质中，可拮抗下颌运动。向腹外侧纹状体注射 SK&F 83959 + 喹吡罗会产生协同作用，但向伏隔核壳注射则不会。这些发现表明腹侧纹状体中与非环化酶偶联的多巴胺 D1 样受体在诱导下颌运动中起主要但非唯一的作用。这些过程似乎需要前额叶环化酶连接的多巴胺 D1A[和/或 D1B]受体的紧张性活动。
