比氏硬核果（漆树科）叶提取物对培养的大鼠骨骼肌细胞钙信号传导的影响。

Effects of Sclerocarya birrea (A. rich) hochst (anacardiaceae) leaf extracts on calcium signalling in cultured rat skeletal muscle cells.

作者信息

Belemtougri R G, Constantin B, Cognard C, Raymond G, Sawadogo L

机构信息

Faculté des Sciences et Techniques, Laboratoire de Physiologie Animale, University of Ouagadougou, Ouagadougou BP 7021, Burkina Faso.

出版信息

J Ethnopharmacol. 2001 Aug;76(3):247-52. doi: 10.1016/s0378-8741(01)00248-3.

DOI:10.1016/s0378-8741(01)00248-3

PMID:11448546

Abstract

Sclerocarya birrea is a plant used widely to treat many diseases in Burkina Faso, although no scientific data has been reported about its mechanism of action. In the present study the effects of its leaf extracts were investigated on calcium signalling in rat cultured skeletal muscle cells. The results show that the different extracts (crude decoction, aqueous, ethanolic and chloroformic extracts) have significant antagonistic effect on caffeine-induced calcium release from sarcoplasmic reticulum. Crude decoction is the most active followed by ethanolic, aqueous and chloroformic extracts in dose-dependent manner and can partly justify the use of the plant in traditional medicine.

摘要

非洲硬核李是布基纳法索广泛用于治疗多种疾病的一种植物，尽管尚未有关于其作用机制的科学数据报道。在本研究中，研究了其叶提取物对大鼠培养骨骼肌细胞钙信号传导的影响。结果表明，不同提取物（粗煎剂、水提取物、乙醇提取物和氯仿提取物）对咖啡因诱导的肌浆网钙释放具有显著的拮抗作用。粗煎剂活性最强，其次是乙醇提取物、水提取物和氯仿提取物，呈剂量依赖性，这在一定程度上可以解释该植物在传统医学中的应用。