Belemtougri R G, Constantin B, Cognard C, Raymond G, Sawadogo L
Laboratory of Physiological Animal, University of Ouagadougou BP 7021, Burkina Faso.
J Zhejiang Univ Sci B. 2006 Jan;7(1):56-63. doi: 10.1631/jzus.2006.B0056.
Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespiliformis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explain their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.
在布基纳法索中部高原广泛用于治疗多种疾病的两种药用植物(番石榴和黑柿)的粗煎剂、水提取物和乙醇提取物,针对其对咖啡因诱导的大鼠骨骼肌细胞肌浆网钙释放的拮抗作用进行了评估。这些不同的提取物均以剂量依赖性方式降低了咖啡因诱导的钙释放。结果比较表明,番石榴叶提取物比黑柿提取物更具活性,且粗煎剂表现出更好的抑制活性。观察到的结果可以解释它们在传统医学中作为抗高血压和止泻剂的用途,即通过抑制细胞内钙释放来实现。