Topaloglu A K, Hallioglu O, Canim A, Duzovali O, Yilgor E
Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin, Turkey.
Nutrition. 2001 Jul-Aug;17(7-8):657-9. doi: 10.1016/s0899-9007(01)00570-6.
A negative correlation between leptin and appetite or food intake has been shown in healthy individuals. However, the role of leptin in clinical conditions characterized by anorexia has not been established. One of the well-known clinical features of iron-deficiency anemia is poor appetite. We examined the changes in plasma leptin levels in relation to expected improvement in appetite with iron treatment in children with iron deficiency. In 24 infants and small children (mean age +/- standard deviation = 19.6 +/- 7.7 months) with iron deficiency, we studied plasma leptin levels before and after iron therapy. After 15.0 +/- 2.4 wk of iron treatment, serum ferritin levels improved significantly, with accompanying increases in their subjective appetite scores and food intakes. However, as their mean age and plasma leptin levels adjusted their body mass indexes were unchanged. Serum ferritin correlated significantly with appetite score (r = 0.680, P < 0.001) and food intake (r = 0.480, P < 0.01). Leptin correlated only with body mass index (r = 0.405, P < 0.01). Lack of association between plasma leptin levels and degree of appetite in iron-deficient children treated with iron suggests a leptin-independent mechanism for the observed increase in appetite.
在健康个体中，瘦素与食欲或食物摄入量之间呈负相关。然而，瘦素在以厌食为特征的临床病症中的作用尚未明确。缺铁性贫血的一个众所周知的临床特征是食欲不佳。我们研究了缺铁儿童在接受铁剂治疗后，血浆瘦素水平的变化与预期食欲改善之间的关系。对24名缺铁婴幼儿（平均年龄±标准差=19.6±7.7个月），我们研究了铁剂治疗前后的血浆瘦素水平。经过15.0±2.4周的铁剂治疗后，血清铁蛋白水平显著改善，同时他们的主观食欲评分和食物摄入量也随之增加。然而，调整平均年龄和血浆瘦素水平后，他们的体重指数并未改变。血清铁蛋白与食欲评分显著相关（r = 0.680，P < 0.001），与食物摄入量也显著相关（r = 0.480，P < 0.01）。瘦素仅与体重指数相关（r = 0.405，P < 0.01）。接受铁剂治疗的缺铁儿童血浆瘦素水平与食欲程度之间缺乏关联，这表明食欲增加是通过一种不依赖瘦素的机制实现的。
