饥饿的讽刺。
Hungry irony.
出版信息
J Clin Invest. 2015 Sep;125(9):3422-3. doi: 10.1172/JCI83193. Epub 2015 Aug 24.
Abstract
Iron-deficient individuals experience a loss of appetite that can be restored with iron supplementation. It has been proposed that iron influences the satiety hormone leptin; however, a direct link between iron and leptin has remained elusive. In this issue of the JCI, Gao and colleagues demonstrate an inverse relationship between adipocyte iron and leptin that is mediated by iron-dependent activation of cAMP-responsive element binding protein (CREB), the transcription factor that represses leptin transcription. Together, the results of this study provide a mechanistic connection between dietary iron and the appetite-regulating hormone leptin.
摘要
缺铁的人会食欲不振，补充铁剂即可恢复食欲。有人提出，铁会影响饱腹感激素瘦素；然而，铁与瘦素之间的直接联系一直难以捉摸。在本期 JCI 中，Gao 及其同事证明了脂肪细胞铁与瘦素之间呈负相关，这种相关性是由铁依赖性激活 cAMP 反应元件结合蛋白 (CREB) 介导的，CREB 是抑制瘦素转录的转录因子。这项研究的结果为膳食铁与调节食欲的激素瘦素之间提供了一种机制联系。
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