Gotta M, Ahringer J
Wellcome/CRC Institute, Tennis Court Road, CB2 1QR, Cambridge, UK.
Curr Opin Genet Dev. 2001 Aug;11(4):367-73. doi: 10.1016/s0959-437x(00)00206-9.
The anterior-posterior axis in Caenorhabditis elegans is determined by the sperm and leads to the asymmetric localisation of PAR (partitioning-defective) proteins, which are critical for polarity. New findings demonstrate that sperm asters play a critical role and suggest models for how PAR asymmetry is established. In addition, studies of blastomere fate determination and heterotrimeric G proteins have started to uncover how initial polarity may be translated into the asymmetric distribution of maternal proteins and the control of spindle position.
秀丽隐杆线虫的前后轴由精子决定，并导致PAR（分区缺陷）蛋白的不对称定位，这些蛋白对极性至关重要。新的研究结果表明精子星体发挥着关键作用，并提出了PAR不对称性如何建立的模型。此外，对卵裂球命运决定和异源三聚体G蛋白的研究已开始揭示初始极性如何转化为母体蛋白的不对称分布以及纺锤体位置的控制。
