囊性纤维化：“碳酸氢根先于氯离子”假说
Cystic fibrosis: the 'bicarbonate before chloride' hypothesis.
作者信息
Wine J J
机构信息
Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305-2130, USA.
出版信息
Curr Biol. 2001 Jun 26;11(12):R463-6. doi: 10.1016/s0960-9822(01)00282-2.
Abstract
The specific effects of some mutations that cause cystic fibrosis suggest that reduced HCO(3)(-) transport is the key to understanding cystic fibrosis pathology. But there is a puzzling discrepancy between measures of CFTR-mediated chloride conductance in expression systems and the sweat chloride values of patients.
摘要
一些导致囊性纤维化的突变的具体影响表明，碳酸氢根（HCO₃⁻）转运减少是理解囊性纤维化病理的关键。但在表达系统中CFTR介导的氯离子电导测量值与患者汗液氯离子值之间存在令人困惑的差异。
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