Schnabel K H, Schmidt W, Schulz V, Gladisch W
Respiration. 1975;32(4):277-83. doi: 10.1159/000193662.
If somebody ascends from sea level to higher altitude within a short time, the change of the atmospheric conditions can be a danger for his life. Therefore, a nomogram was constructed which allows to read off the arterial oxygen partial pressures and the corresponding arterial oxygen saturation in relation to altitude. On the basis of the oxygen partial pressure of the atmosphere determined by steps of 500 m from sea level up to an antitude of 10,000 m, we calculated the decrease of the oxygen partial pressure from the inspired air to the arterial blood. When passing our airways, the inspired oxygen partial pressure is dimished by the adaptation to BTPS conditions and by the increasing CO2 partial pressure when approaching the alveolar gas exchanging zone. Another oxygen partial pressure gradient formed by inhomogeneities of ventilation to perfusion, diffusing capacity to perfusion and shunt perfusion is found at the alveolar-arterial barrier. The value of this alveolar-arterial oxygen partial pressure difference is closely correlated to age. With the values of the single steps, the nomogram was constructed. Seven abscissas show the oxygen partial pressure gradients from the inspired air at a distinct altitude to the arterial blood. In relation to a lot of CO2-depending oxygen dissociation curves, it is possible to read off additionally the corresponding arterial oxygen saturation for a person in rest up to an altitude of 10,000 m.
如果有人在短时间内从海平面上升到更高海拔,大气条件的变化可能会危及生命。因此,构建了一种列线图,可据此读出与海拔相关的动脉血氧分压和相应的动脉血氧饱和度。基于从海平面到10000米海拔以500米为步长确定的大气氧分压,我们计算了从吸入空气到动脉血的氧分压下降。在通过气道时,吸入的氧分压会因适应体温、气压、饱和水蒸气压力(BTPS)条件以及在接近肺泡气体交换区时二氧化碳分压的增加而降低。在肺泡 - 动脉屏障处还发现了由通气与灌注不均匀、弥散能力与灌注以及分流灌注形成的另一个氧分压梯度。这个肺泡 - 动脉血氧分压差的值与年龄密切相关。利用这些单一步长的值构建了列线图。七条横坐标显示了在特定海拔下从吸入空气到动脉血的氧分压梯度。结合许多依赖二氧化碳的氧解离曲线,还可以读出在海拔10000米以下休息状态下人的相应动脉血氧饱和度。