Yoshitatsu S, Takagi T, Ohata C, Kozuka T
Department of Plastic Surgery, Osaka National Hospital, 2-1-14, Hoenzaka, Chuou-ku, Osaka 540-0006, Japan.
J Dermatol. 2001 Apr;28(4):226-30. doi: 10.1111/j.1346-8138.2001.tb00122.x.
Verrucous carcinoma is a relatively rare, well-differentiated, squamous cell carcinoma. Although it is slow-growing and mimics benign skin lesions, it can cause extensive local destruction that necessitates amputation. It is often underdiagnosed as a benign tumor in its early course. We report a case of extensive verrucous carcinoma on a recalcitrant ulcer and a severe long-standing scar around it on the sole of the right forefoot, which had been treated as a benign tumor for more than two years. We treated it successfully with amputation of the foot and were able to spare the heel by using a free innervated forearm flap to cover the defect at the stump. The present case should remind clinicians that a verrucous lesion developing on a refractory ulcer may be a complex malignant neoplasm; an accurate diagnosis is difficult without a combination of clinical features and pathological findings from an adequately deep specimen.
疣状癌是一种相对罕见的、高分化的鳞状细胞癌。尽管其生长缓慢且类似良性皮肤病变,但它可导致广泛的局部破坏,从而需要截肢。在其病程早期,它常被误诊为良性肿瘤。我们报告一例右前足底顽固性溃疡及其周围严重长期瘢痕上的广泛性疣状癌病例,该病例被当作良性肿瘤治疗了两年多。我们通过足部截肢成功治疗了该病例,并使用带神经支配的游离前臂皮瓣覆盖残端缺损,从而保留了足跟。本病例应提醒临床医生,难治性溃疡上出现的疣状病变可能是一种复杂的恶性肿瘤;若无临床特征和足够深度标本的病理结果相结合,准确诊断是困难的。