Division of Dermatology, University of Vermont, Burlington, Vermont, USA.
Dermatol Online J. 2024 Mar 15;30(1). doi: 10.5070/D330163293.
Verrucous carcinoma (VC) is a rare, low-grade variant of well-differentiated squamous cell carcinoma. Plantar verrucous carcinoma presents as a slow-growing, exophytic, verrucous plaque on weight bearing areas of the foot. Verrucous carcinomas have low metastatic potential, but are high risk for local invasion. We describe a patient with a 20-year history of a slowly growing, ulcerated, verrucous plaque on the sole of the left foot that was erroneously treated for years as verruca plantaris and was eventually diagnosed as invasive verrucous carcinoma. Verrucous carcinomas are a diagnostic challenge due to clinical and histopathologic mimicry of benign lesions. Mohs micrographic surgery should be employed to allow the ability to intraoperatively assess tumor margins while excising the minimal amount of necessary tissue. It is important for clinicians to recognize the characteristics and accurately diagnose verrucous carcinomas. Delays in treatment may require more extensive dissection or amputation.
疣状癌（VC）是一种罕见的、分化良好的鳞状细胞癌的低级别变体。足底疣状癌表现为生长缓慢、外生性、疣状斑块，位于足部承重区域。疣状癌转移潜能低，但局部侵袭风险高。我们描述了一名患者，其左足底有一个 20 年病史的缓慢生长、溃疡性、疣状斑块，多年来被误诊为足底寻常疣，并最终被诊断为侵袭性疣状癌。疣状癌在临床上和组织病理学上与良性病变相似，因此具有诊断挑战性。Mohs 显微外科手术应该被采用，以便在切除必要的最小组织量的同时，能够在术中评估肿瘤边缘。临床医生识别疣状癌的特征并准确诊断非常重要。治疗延误可能需要更广泛的解剖或截肢。
