[Extracellular immunoreactive nucleoprotein of Influenza virus not related to the virion].
作者信息
Prokudina E N, Semenova N P, Chumakov V M, Rudneva I A
出版信息
Vopr Virusol. 2001 May-Jun;46(3):21-6.
PMID:11450139
Abstract
Extracellular immunoreactive virus NP is accumulated in virus-containing fluid in the course of A/Duck/Ukraine/1/63(H3N8) influenza virus infection. The major part of this extracellular NP is included in viral RNP and characterized by relatively low molecular weight: 53 kD vs. 56 kD of virion NP. Extracellular immunoreactive NP is oligomerized. Presumably, there is partially intracellular cleavage of NP with loss of hydrophobic determinants. Such truncated NP in RNP is highly hydrophilic and passes through cell membranes. These data prompt the diagnosis of influenza infection by detection of free immunoreactive NP in analyzed fluids.
摘要
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