Semenova N P, Chumakov V M, Rudneva I A, Prokudina E N
Vopr Virusol. 1998 Jan-Feb;43(1):24-9.
Oligomerization of influenza virus nucleoprotein (NP) depends on the virus strain. NP monomers of viruses A/Duck/Ukraine/63 (H3N8) and A/Seal/Massachusets/1/80/ (H7N7) are oligomerized completely. The A/USSR/90/77 virus (H1N1) NP is characterized by just partial oligomerization, similarly as a reassortant containing surface protein genes of virus A/Duck/Ukraine and internal protein genes of A/USSR/90 virus. Hence, it is probable that NP gene controls the type of NP oligomerization. NP oligomerization is shown to depend on the temperature, the optimal t = 37 degrees C, but not on the type of cells or intracellular concentration of total NP. NP oligomers forming in vivo are believed to differ from NP oligomers formed in vitro described previously.
流感病毒核蛋白（NP）的寡聚化取决于病毒株。A/鸭/乌克兰/63（H3N8）和A/海豹/马萨诸塞州/1/80/（H7N7）病毒的NP单体完全寡聚化。A/苏联/90/77病毒（H1N1）的NP的特征是只是部分寡聚化，类似于一种含有A/鸭/乌克兰病毒表面蛋白基因和A/苏联/90病毒内部蛋白基因的重配体。因此，NP基因很可能控制NP寡聚化的类型。已表明NP寡聚化取决于温度，最佳温度t = 37℃，但不取决于细胞类型或总NP的细胞内浓度。据信在体内形成的NP寡聚体与先前描述的体外形成的NP寡聚体不同。
