Gomperts E D, Zail S S, Christensen D, Metz J
Scand J Haematol. 1975 Apr;14(2):81-5. doi: 10.1111/j.1600-0609.1975.tb00299.x.
The administration of vitamin E, a natural antioxidant, to a patient with paroxysmal nocturnal haemoglobinuria (PNH) failed to diminish the urinary excretion of 59-Fe as monitored by 59-Fe whole body counting and urinary loss of isotope. However, in vitro vitamin E corrected the increased sensitivity of PNH red cells to haemolysis by hydrogen peroxide. These results support the concept that the susceptibility of PNH red cells to lipid peroxidation is an in vitro phenomenon bearing little relation to the mechanism of in vivo haemolysis.
给阵发性夜间血红蛋白尿（PNH）患者服用天然抗氧化剂维生素E，通过59-Fe全身计数和同位素尿流失监测发现，并未减少59-Fe的尿排泄量。然而，在体外，维生素E纠正了PNH红细胞对过氧化氢溶血敏感性的增加。这些结果支持了以下概念，即PNH红细胞对脂质过氧化的易感性是一种体外现象，与体内溶血机制关系不大。
