通过血浆溶菌酶测定皮质类固醇诱导的中性粒细胞增多症中的中性粒细胞动力学。

Neutrophil kinetics in corticosteroid induced neutrophilia measured by plasma lysozyme.

作者信息

Karle H, Hansen N E

出版信息

Scand J Haematol. 1975 May;14(3):190-5. doi: 10.1111/j.1600-0609.1975.tb00316.x.

DOI:10.1111/j.1600-0609.1975.tb00316.x

Abstract

A single dose of prednisone (2 mg/kg orally) resulted in a mean rise in neutrophil counts to 2.3 (range 1.5-3.6) and a mean decrease in plasma lysozyme to 0.73 (range 0.50-0.87) times the value before the steroid was given in 10 haematologically normal persons. There was no change in the intraneutrophilic lysozyme activity. It is concluded that the decrease in plasma lysozyme is compatible with a reduction in the egress of neutrophils to the tissues and a decrease in the neutrophil turnover rate.

摘要

对10名血液学检查正常的人单次口服泼尼松（2毫克/千克）后，中性粒细胞计数平均升至2.3（范围为1.5 - 3.6），血浆溶菌酶平均降至给药前值的0.73（范围为0.50 - 0.87）倍。中性粒细胞内溶菌酶活性无变化。结论是，血浆溶菌酶的降低与中性粒细胞向组织的逸出减少以及中性粒细胞周转率降低相一致。