Dick W
Monatsschr Kinderheilkd (1902). 1980 Jan;128(1):30-3.
Serum levels of lysozyme were studied in 43 term and 36 premature newborns. Levels in premature babies were found to be significantly (p less than 0,001) lower than those of matures. Observation over two weeks revealed a rise of serum lysozyme in premature babies and a decline in mature newborns. The level seems to depend upon the turnover of neutrophile granulocytes. In 5 premature babies with clinical signs of sepsis the serum lysozyme concentrations were significantly (p less than 0,01) lower than those in healthy prematures. It is assumed that the activity of the intraneutrophilic lysozyme in patients with bacterial infections is reduced to as little as 50%. Urine controls for lysozyme in 43 newborns (mature and premature) did not show evidence of measurable lysozyme concentrations.
对43名足月儿和36名早产儿的血清溶菌酶水平进行了研究。发现早产儿的血清溶菌酶水平显著低于足月儿（p<0.001）。为期两周的观察显示，早产儿血清溶菌酶水平升高，而足月儿血清溶菌酶水平下降。血清溶菌酶水平似乎取决于中性粒细胞的更新率。5名有败血症临床症状的早产儿血清溶菌酶浓度显著低于健康早产儿（p<0.01）。据推测，细菌感染患者中性粒细胞内溶菌酶的活性降低至仅50%。对43名新生儿（足月儿和早产儿）尿液中的溶菌酶进行检测，未发现可测量的溶菌酶浓度。
