用氯唑西林和双氯西林治疗慢性葡萄球菌骨髓炎——12例患者的对比研究

Treatment of chronic staphylococcal osteomyelitis with cloxacillin and dicloxacillin--a comparative study in 12 patients.

作者信息

Hedström S A

出版信息

Scand J Infect Dis. 1975;7(1):55-7. doi: 10.3109/inf.1975.7.issue-1.10.

DOI:10.3109/inf.1975.7.issue-1.10

Abstract

12 patients with chronic staphylococcal osteomyelitis were treated with cloxacillin (6 patients) and dicloxacillin (6 patients) in a prospective, comparative study. The drugs were given perorally in the dose 1 g every 4th hour and serum concentrations were followed. 0.5, 1 and 2 hours after administration the serum level of dicloxacillin was about double that of cloxacillin. The lowest serum level of dicloxacillin at the time of administration of the drugs was nearly 3 times as high as the level of cloxacillin. An evaluation of clinical benefit and side-effects revealed no differences between the drugs. The prolonged serum level of dicloxacillin may permit a longer interval between doses than the administration of cloxacillin.

摘要

在一项前瞻性对比研究中，12例慢性葡萄球菌性骨髓炎患者接受了氯唑西林（6例患者）和双氯西林（6例患者）治疗。药物每4小时口服1克，并监测血清浓度。给药后0.5、1和2小时，双氯西林的血清水平约为氯唑西林的两倍。给药时双氯西林的最低血清水平几乎是氯唑西林的3倍。对临床疗效和副作用的评估显示，两种药物之间没有差异。双氯西林血清水平的延长可能允许给药间隔比氯唑西林更长。