Bell S M
Med J Aust. 1976 Oct 16;2(16):591-3. doi: 10.5694/j.1326-5377.1976.tb115265.x.
This report confirms after periods of observation of up to nine years, the successful treatment with high oral doses of cloxacillin or phenoxymethylpenicillin of 19 patients suffering from chronic staphylococcal osteomyelits. The antibiotic treatment was closely supervised over long periods, and the satisfactory response initially reported has been maintained in each case. Brief reference is made also to the use of the same treatment in a further 191 patients with chronic staphylococcal bone infection. Observations of the progress of 136 of these patients are continuing. At this stage the response in these patients confirms the value in chronic osteomyelitis of the long-term treatment with these penicillins which was established in the first 19 patients treated.
本报告证实，经过长达九年的观察期，19例慢性葡萄球菌性骨髓炎患者采用高剂量口服氯唑西林或苯氧甲基青霉素治疗成功。长期密切监测抗生素治疗情况，且最初报告的满意疗效在每个病例中均得以维持。文中还简要提及了另外191例慢性葡萄球菌性骨感染患者采用相同治疗方法的情况。对其中136例患者病情进展的观察仍在继续。现阶段，这些患者的治疗反应证实了在最初治疗的19例患者中所确立的这些青霉素长期治疗慢性骨髓炎的价值。
