Lyrdal F, Olin T
Scand J Urol Nephrol. 1975;9(2):151-60. doi: 10.3109/00365597509180922.
The renal artery was occluded in rabbits for varying lengths of time with the aid of a balloon catheter. Before and after the period of ischaemia, renal blood flow was measured by a dye-dilution technique and the glomerular and tubular functions were evaluated by measuring the extractions of labelled EDTA and Hippuran. Prolongation of the period of continuous ischaemia from 15 to 60 minutes resulted in a progressive increase in the postocclusive hyperaemia, but in a reduction of the renal function. Compared with 30 minutes of continuous occlusion, 30 minutes of intermittent occlusion caused only slight hyperaemia, but the same degree of reduction in renal function. One day after 30 minutes or 60 minutes of ischaemia, renal blood flow was within the range of the normal flow. After 30 minutes of occlusion, renal function was re-established 7 days later, whereas after 60 minutes of ischaemia, function was still severely impaired 7 days later. Fourteen days after 60 minutes of occlusion, renal function was 50% or less of the normal. Juxtamedullary shunting has not been demonstrated in the present investigation. Metabolic changes and cellular damage remain as possible explanations of the postocclusive changes in renal blood flow and function.
借助球囊导管，对家兔的肾动脉进行不同时长的阻断。在缺血期前后，采用染料稀释技术测量肾血流量，并通过测量标记的乙二胺四乙酸（EDTA）和马尿酸的摄取量来评估肾小球和肾小管功能。将持续缺血时间从15分钟延长至60分钟，会导致闭塞后充血逐渐增加，但肾功能会降低。与持续闭塞30分钟相比，间歇性闭塞30分钟仅引起轻微充血，但肾功能降低程度相同。缺血30分钟或60分钟后一天，肾血流量在正常流量范围内。闭塞30分钟后，7天后肾功能恢复，而缺血60分钟后，7天后功能仍严重受损。闭塞60分钟后14天，肾功能仅为正常的50%或更低。在本研究中未证实存在近髓分流。代谢变化和细胞损伤仍然可能是肾血流量和功能闭塞后变化的原因。
