Lyrdal F, Olin T
Scand J Urol Nephrol. 1975;9(2):161-8. doi: 10.3109/00365597509180923.
After 1, 2, 4, 7, 14 and 21 days of ureteral occlusion, renal blood flow was measured on both sides by means of a dye-dilution method and the glomerular and tubular functions were evaluated by measuring the extraction of 51-Cr-EDTA and 125-I-Hippuran. The results showed an increase in the weight of the obstructed kidney parenchyma and indicated an incipient compensatory hypertrophy of the contralateral kidney after 14 days of occlusion. The blood flow to the occluded kidney was reduced on the first day after ligation and ranged in all experiments between 24% and 44% of the total renal blood flow, without correlation to the duration of stasis. The blood flow to the contralateral kidney was mostly above the average in the control group. A small glomerular and tubular extraction was noted in more than 50% of the ligated kidneys. The glomerular filtration rate and the clearance of Hippuran by the contralateral kidney were increased after one day of occlusion, but no relationship between the changes in renal function and the duration of ligation was revealed. It is concluded that ureteral ligation causes a decrease in the blood flow to the occluded kidney and an increase in that to the contralateral kidney. The function of the contralateral kidney increases initially, but thereafter only as a consequence of the compensatory hypertrophy which is evident around the 14th day post occlusion.
在输尿管梗阻1天、2天、4天、7天、14天和21天后，采用染料稀释法测量双侧肾血流量，并通过测量51-铬-乙二胺四乙酸（51-Cr-EDTA）和125-碘-马尿酸（125-I-Hippuran）的摄取量来评估肾小球和肾小管功能。结果显示，梗阻侧肾实质重量增加，表明梗阻14天后对侧肾开始出现代偿性肥大。结扎后第一天，梗阻侧肾脏的血流量减少，在所有实验中占总肾血流量的24%至44%，与淤血持续时间无关。对侧肾脏的血流量大多高于对照组的平均值。在超过50%的结扎肾脏中观察到肾小球和肾小管摄取量较小。梗阻一天后，对侧肾脏的肾小球滤过率和马尿酸清除率增加，但未发现肾功能变化与结扎持续时间之间的关系。结论是，输尿管结扎导致梗阻侧肾脏血流量减少，对侧肾脏血流量增加。对侧肾脏的功能最初增加，但此后仅作为梗阻后第14天左右明显的代偿性肥大的结果。
