Sotanieme E A, Kontture M J
Scand J Urol Nephrol. 1975;9(2):89-93. doi: 10.3109/00365597509180912.
The effect of diethylstilboestrol diphosphate (DES) and polyestradiol phosphate (PES) on the serum lipid levels of 40 prostatic cancer patients was investigated during a long-term follow-up. In patients treated with DES serum triglyceride levels elevated significantly whereas changes in serum cholesterol and total lipid contents were not significant. In patients treated with PES no significant changes in serum triglyceride, cholesterol and total lipid levels were found. Nineteen out of 40 (48%) of patients developed cardiovasculat complications during the trial; 11 had cerebrovascular attacks, 5 coronary occlusion and 3 thromboembolism in the leg. There was a significant increase in serum triglyceride levels in all patients who developed vascular disorders, whereas the changes in serum cholesterol and total lipids were not significant. The results suggest a possible association between the increase of serum triglycerides and the development of thromboembolic complications.
在长期随访过程中，研究了磷酸己烯雌酚（DES）和磷酸聚雌二醇（PES）对40例前列腺癌患者血脂水平的影响。接受DES治疗的患者血清甘油三酯水平显著升高，而血清胆固醇和总脂质含量变化不显著。接受PES治疗的患者，血清甘油三酯、胆固醇和总脂质水平未发现显著变化。40例患者中有19例（48%）在试验期间出现心血管并发症；11例发生脑血管意外，5例冠状动脉闭塞，3例腿部血栓栓塞。所有发生血管疾病的患者血清甘油三酯水平均显著升高，而血清胆固醇和总脂质变化不显著。结果提示血清甘油三酯升高与血栓栓塞并发症的发生之间可能存在关联。
