Eisen M, Napp H E, Vock R
J Urol. 1975 Jul;114(1):93-7. doi: 10.1016/s0022-5347(17)66952-0.
Platelet aggregation is increased in patients with carcinoma of the prostate treated with estrogens. Hence, these patients have a high incidence of cardiovascular and thromboembolic diseases. Platelet aggregation has been tested with the platelet aggregation test. It was inhibited by administration of 500 mg. acetylsalicylic acid twice daily. An aggregation inhibiting effect has been found in all 38 patients. To reduce the excess hazards of cardiovascular complications of estrogens in treating carcinoma of the prostate acetylsalicylic acid is recommended as an adjunct therapy.
接受雌激素治疗的前列腺癌患者血小板聚集增加。因此，这些患者心血管疾病和血栓栓塞性疾病的发病率很高。血小板聚集已通过血小板聚集试验进行检测。每天两次服用500毫克乙酰水杨酸可抑制血小板聚集。在所有38例患者中均发现有聚集抑制作用。为降低雌激素治疗前列腺癌时心血管并发症的额外风险，建议将乙酰水杨酸作为辅助治疗。
