Seiler M W, Venkatachalam M A, Cotran R S
Science. 1975 Aug 1;189(4200):390-3. doi: 10.1126/science.1145209.
Perfusion of rat kidneys with the polycation protamine sulfate caused glomerular epithelial alterations resembling those observed in human and experimental nephrotic states. The changes included swelling, blunting, and flattening of epithelial foot processes, were accompanied by decreased stainability of glomerular anionic sites, and were largely reversed by subsequent perfusion with the polyanion heparin.
用聚阳离子硫酸鱼精蛋白灌注大鼠肾脏，会引起肾小球上皮改变，类似于在人类和实验性肾病状态中观察到的改变。这些变化包括上皮足突肿胀、变钝和变平，同时伴有肾小球阴离子位点染色性降低，随后用聚阴离子肝素灌注可在很大程度上逆转这些变化。
