Chen Jingyi, Yang Miaoxin, Zhang Qiang, Cho Eun Chul, Cobley Claire M, Kim Chulhong, Glaus Charles, Wang Lihong V, Welch Michael J, Xia Younan
Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Adv Funct Mater. 2010 Nov 9;20(21):3684-3694. doi: 10.1002/adfm.201001329. Epub 2010 Oct 4.
Gold nanocages represent a novel class of nanostructures, well-suited for biomedical applications. They can be readily prepared via the galvanic replacement reaction between silver nanocubes and chloroauric acid. Their optical resonance peaks can be easily and precisely tuned to the near-infrared region from 650-900 nm, the transparent window for blood and soft tissue. Furthermore, their surface can be conveniently conjugated with various ligands for targeting cancer. In this feature article, we highlight recent advances in the large-scale synthesis of gold nanocages and their applications in cancer diagnosis and treatment. Specifically, we have scaled up the production of gold nanocages for in vivo studies and evaluated their tumor targeting capabilities. We have also demonstrated their use as contrast agents for photoacoustic tumor imaging and the mapping of sentinel lymph node, as photothermal transducers for cancer treatment, and as smart carriers for controlled release with a near-infrared laser.
金纳米笼代表了一类新型的纳米结构，非常适合生物医学应用。它们可以通过银纳米立方体与氯金酸之间的电化学生长反应轻松制备。它们的光学共振峰可以轻松且精确地调谐到650 - 900纳米的近红外区域，这是血液和软组织的透明窗口。此外，它们的表面可以方便地与各种用于靶向癌症的配体结合。在这篇专题文章中，我们重点介绍了金纳米笼大规模合成及其在癌症诊断和治疗中的应用的最新进展。具体而言，我们已经扩大了用于体内研究的金纳米笼的生产规模，并评估了它们的肿瘤靶向能力。我们还展示了它们作为光声肿瘤成像和前哨淋巴结定位的造影剂、作为癌症治疗的光热换能器以及作为用近红外激光进行控释的智能载体的用途。
