胶原脯氨酸和赖氨酸羟基化的分子轨道研究。
Molecular-orbital study of hydroxylation of collagenous proline and lysine.
作者信息
Zahradník R, Hobza P, Hurych J
机构信息
Institute of Physical Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia.
出版信息
Biochim Biophys Acta. 1971 Dec 28;251(3):314-9. doi: 10.1016/0005-2795(71)90117-6.
PMID:11452871
Abstract
EHT and CNDO/2 types of calculations permit the interpretation of the course of hydroxylation of collagenous proline and lysine. Calculations were performed for the models of proline (I), zwitterion of proline (II), proline-containing peptide (III), and lysine (IV). The theoretical results are consistent with an electrophilic mechanism.
摘要
EHT和CNDO/2类型的计算允许对胶原蛋白脯氨酸和赖氨酸的羟基化过程进行解释。对脯氨酸（I）、脯氨酸两性离子（II）、含脯氨酸肽（III）和赖氨酸（IV）的模型进行了计算。理论结果与亲电机制一致。
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