Hake A M
Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA.
Cleve Clin J Med. 2001 Jul;68(7):608-9, 613-4, 616. doi: 10.3949/ccjm.68.7.608.
The four cholinesterase inhibitors now available for treatment of Alzheimer disease (AD) may be most beneficial, especially in the long run, if started early in the course of the disease. This paper reviews the efficacy, pharmacokinetics, metabolism, side effects, dosage, and precautions for the use of these agents, which may produce modest improvements in cognition, behavior, and the ability to perform activities of daily living.
目前可用于治疗阿尔茨海默病（AD）的四种胆碱酯酶抑制剂，如果在疾病进程早期开始使用，可能最为有益，尤其是从长远来看。本文综述了这些药物的疗效、药代动力学、代谢、副作用、剂量及使用注意事项，它们可能会使认知、行为及日常生活活动能力有适度改善。
