Scherer K, Lorenz S, Wimmershoff M, Landthaler M, Hohenleutner U
Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany.
Br J Dermatol. 2001 Jul;145(1):79-84. doi: 10.1046/j.1365-2133.2001.04285.x.
At present, laser therapy of port-wine stains (PWS) using the flashlamp-pumped dye laser (FPDL) at 450 micros is accepted as the optimal approach. A few years ago, a new long-pulsed tunable dye laser (LPTDL, 1.5 ms) was introduced for the treatment of leg veins.
To investigate the efficacy and side-effects of FPDL vs. LPTDL therapy of PWS.
Sixty-two patients with untreated PWS underwent test treatments with the FPDL (585 nm; 7-mm spot size; 5.75--7.0 J cm(-2) fluence) and LPTDL (585, 590, 595, 600 nm; 5-mm spot size; 11--20 J cm(-2) fluence). With the LPTDL, the epidermis was additionally cooled (Spray cooling device). The fading was evaluated clinically 6 weeks after the test treatments.
Optimal fading was achieved by the LPTDL (> or = 585 nm) in 30 patients and by the FPDL in 12 patients. No difference was found in 20 patients. At 585 nm, the lasers worked equally well in 12 (FPDL) and 13 (LPTDL) patients, respectively. Results were independent of the localization of the PWS and of the patient's age. In spite of the longer pulse duration, the LPTDL treatment did not result in more side-effects as long as sufficient cooling was provided.
The results provide evidence that wavelengths longer than 585 nm can increase the efficacy of treatment in some PWS. Owing to the reduced light absorption by haemoglobin at longer wavelengths and consequently increased depth of the vascular injury, larger vessels can be damaged more adequately using an increased fluence. The LPTDL at 585 nm seemed to be slightly superior to the FPDL, while accepting that due to technical reasons the laser parameters were not directly comparable. Availability of both lasers increases the therapeutic possibilities in PWS.
目前,采用波长450微米的闪光灯泵浦染料激光(FPDL)治疗鲜红斑痣(PWS)被认为是最佳方法。几年前,一种新型长脉冲可调染料激光(LPTDL,脉宽1.5毫秒)被用于治疗腿部静脉。
研究FPDL与LPTDL治疗PWS的疗效及副作用。
62例未经治疗的PWS患者分别接受FPDL(585纳米;光斑直径7毫米;能量密度5.75 - 7.0焦/平方厘米)和LPTDL(585、590、595、600纳米;光斑直径5毫米;能量密度11 - 20焦/平方厘米)的试验性治疗。使用LPTDL时,表皮额外进行冷却(喷雾冷却装置)。试验性治疗6周后进行临床褪色评估。
30例患者使用LPTDL(波长≥585纳米)实现了最佳褪色,12例患者使用FPDL实现了最佳褪色。20例患者未发现差异。波长585纳米时,两种激光分别在12例(FPDL)和13例(LPTDL)患者中效果相同。结果与PWS的部位及患者年龄无关。尽管LPTDL脉宽较长,但只要有足够的冷却,其治疗不会导致更多副作用。
结果表明,波长大于585纳米可提高部分PWS的治疗效果。由于血红蛋白在较长波长下光吸收减少,从而增加了血管损伤深度,使用更高的能量密度可更充分地损伤较大血管。585纳米的LPTDL似乎略优于FPDL,但由于技术原因,两种激光的参数无法直接比较。两种激光的应用增加了PWS的治疗可能性。